Repetition, revision, appropriation and the Western

The aim of this research paper is to demonstrate the innate dialogue that exists between the Western genre and Contemporary Art practice. Initially, the fundamental qualities of a ‘Classic’ Western are defined, before moving on to a broader examination of the genre’s key developments and evolutions post World War II. Using George Steven’s Shane as a case study, the paper traces the prominent position of appropriation inside the meta-cinematic form, whilst also tying various filmic examples to the practice’s of visual artists who employ congruous strategies when developing their own work. The paper concludes with a detailed exploration of my own creative practice, highlighting how my theoretical research has informed a body of work that employs prominent connections and appropriations from both cinematic and artistic forms of expression. The exhibited component of my studio research is a three part installation and accompanying online database of film stills. Each piece in the body of work explores the position of the Western genre in the cinematic and contemporary art contexts, representing a refined culmination of my various work and its development through a sustained process of visual and theoretical investigation. All four parts of the project employ the well established revisionist imperatives that characterise the Western and Contemporary Art spheres. Through the combination of these shared practices my work seeks to hybridise the two traditionally separate, but increasingly homogeneous creative mediums

Circadian rhythms and epilepsy:A suitable case for absence epilepsy

Contains fulltext : 218494.pdf (publisher's version ) (Open Access)Many physiological processes such as sleep, hormonal secretion, or thermoregulation, are expressed as daily rhythms orchestrated by the circadian timing system. A powerful internal clock mechanism ensures proper synchronization of vital functions within an organism on the one hand, and between the organism and the external environment on the other. Some of the pathological processes developing in the brain and body are subjected to circadian modulation as well. Epilepsy is one of the conditions which symptoms often worsen at a very specific time of a day. Variation in peak occurrence depends on the syndrome and localization of the epileptic focus. Moreover, the timing of some types of seizures is closely related to the sleep-wake cycle, one of the most prominent circadian rhythms. This review focuses on childhood absence epilepsy (CAE), a genetic generalized epilepsy syndrome, in which both, the circadian and sleep influences play a significant role in manifestation of symptoms. Human and animal studies report rhythmical occurrence of spike-wave discharges (SWDs), an EEG hallmark of CAE. The endogenous nature of the SWDs rhythm has been confirmed experimentally in a genetic animal model of the disease, rats of the WAG/Rij strain. Well-known detrimental effects of circadian misalignment were demonstrated to impact the severity of ongoing epileptic activity. SWDs are vigilance-dependent in both humans and animal models, occurring most frequently during passive behavioral states and light slow-wave sleep. The relationship with the sleep-wake cycle seems to be bidirectional, while sleep shapes the rhythm of seizures, epileptic phenotype changes sleep architecture. Circadian factors and the sleep-wake states dependency have a potential as add-ons in seizures' forecasting. Stability of the rhythm of recurrent seizures in individual patients has been already used as a variable which refines existing algorithms for seizures' prediction. On the other hand, apart from successful pharmacological approach, circadian hygiene including sufficient sleep and avoidance of internal desynchronization or sleep loss, may be beneficial for patients with epilepsy in everyday management of seizures.13 p

Experimental treatment options in absence epilepsy

Contains fulltext : 182124.pdf (preprint version ) (Open Access)Background: The benign character of absence epilepsy compared to other genetic generalized epilepsy syndromes has often hampered the search for new treatment options. Absence epilepsy is most often treated with ethosuximide or valproic acid. However, both drugs are not always well tolerated or fail, and seizure freedom for a larger proportion of patients remains to be achieved. The availability of genuine animal models of epilepsy does allow to search for new treatment options not only for absence epilepsy perse but also for other genetic - previously called idiopathic - forms of epilepsy. The recent discovery of a highly excitable cortical zone in these models is considered as a new therapeutic target area. Methods: Here, we provide an overview regarding the search for new therapeutical options as has been investigated in the genetic rodent models (mainly WAG/Rij and GAERS) including drugs and whether antiepileptogenesis can be achieved, various types of electrical and optogenetical invasive stimulations, different types of non-invasive stimulation and finally whether absence seizures can be predicted and prevented. Results: Many factors determine either the cortical and or thalamic excitability or the interaction between cortex and thalamus and offer new possibilities for new anti-absence drugs, among others metabotropic glutamatergic positive and negative allosteric modulators. The inhibition of epileptogenesis by various drugs with its widespread consequences seems feasible, although its mechanisms remain obscure and seems different from the anti-absence action. Surgical intervention on the cortical zone initiating seizures, either with radiosurgery using synchrotron-generated microbeams, or ablation techniques might reduce spike-and-wave discharges in the rodent models. High frequency electrical subcortical or cortical stimulation might be a good way to abort ongoing spike-and-wave discharges. In addition, possibilities for prevention with real-time EEG analyses in combination with electrical stimulation could also be a way to fully control these seizures. Conclusion: Although it is obvious that some of these treatment possibilities will not be used for absence epilepsy and/or need to be further developed, all can be considered as proof of principle and provide clear directives for further developments

Automatic roI detection for camera-based pulse-rate measurement

Remote photoplethysmography (rPPG) enables contactless measurement of pulse-rate by detecting pulse-induced colour changes on human skin using a regular camera. Most of existing rPPG methods exploit the subject face as the Region of Interest (RoI) for pulse-rate measurement by automatic face detection. However, face detection is a suboptimal solution since (1) not all the subregions in a face contain the skin pixels where pulse-signal can be extracted, (2) it fails to locate the RoI in cases when the frontal face is invisible (e.g., side-view faces). In this paper, we present a novel automatic RoI detection method for camerabased pulse-rate measurement, which consists of three main steps: subregion tracking, feature extraction, and clustering of skin regions. To evaluate the robustness of the proposed method, 36 video recordings are made of 6 subjects with different skin-types performing 6 types of head motion. Experimental results show that for the video sequences containing subjects with brighter skin-types and modest body motions, the accuracy of the pulse-rates measured by our method (94 %) is comparable to that obtained by a face detector (92 %), while the average SNR is significantly improved from 5.8 dB to 8.6 dB

Metabotropic glutamate receptors as drug targets for the treatment of absence epilepsy

Metabotropic glutamate (mGlu) receptors are expressed in key regions of the cortex and the thalamus and are known to regulate spike and wave discharges (SWDs), the electroclinical hallmarks of absence seizures. Recent preclinical studies have highlighted the therapeutic potential of selective group I and III mGlu receptor subtype allosteric modulators, which can suppress pathological SWDs. Of particular interest are positive allosteric modulators (PAMs) for mGlu5 receptors, as they currently show the most promise as novel anti-absence epilepsy drugs. The rational design of novel selective positive and negative allosteric mGlu modulators, especially for the mGlu5 receptor, has been made possible following the recent crystallographic structure determination of group I mGlu receptors. Our current knowledge of the role of different mGlu receptor subtypes in absence epilepsy is outlined in this article. [Abstract copyright: Copyright © 2018. Published by Elsevier Ltd.

The Maslach-Trisni Burnout Inventory: Adaptation for IndonesiaJP3I (Jurnal Pengukuran Psikologi dan Pendidikan Indonesia)

Abstract Burnout is commonly measured with the Maslach Burnout Inventory (MBI), which consists of three subscales measuring emotional exhaustion, personal accomplishment, and cynicism. We adapted the scale and then explored and confirmed the three dimensions on the Indonesian version named The Maslach-Trisni Burnout Inventory (M-TBI) with an exploratory analysis followed by Confirmatory Factor Analysis (CFA) from 822 workforces. The sensitivity for different job characteristics and demographic factors was established with analyses of variance and based on percentile scores of the subscales, three categories for burnout tendency were proposed. The scores on the three subscales were compared with those of Western countries. There are similar scores for emotional exhaustion and cynicism, but the sample score for personal accomplishment tends to be lower than the western countries. It can be concluded that the M-TBI scale is a reliable, sensitive, and efficient tool to measure the burnout tendency in the workforce in Indonesia. Keywords: adaptation scale, burnout, factor analysi

Slow Late Component in Conditioned Stimulus-Evoked Potentials From the Amygdala After Fear Conditioning in the Rat

Male Wistar rats were subjected to a differential Pavlovian fear conditioning procedure in which one of two tones (6 or 10 kHz) was followed by an electric shock (CS+) and the other was not (CS-). Before and after fear conditioning, we recorded the evoked potentials elicited by CS+ and CS- from electrodes aimed at the lateral nucleus of the amygdala. Before conditioning, a slow, negative component with peak amplitude around 150 ms was present in the evoked potentials. This component was sensitive to habituation. After fear conditioning, both CS+ and CS- elicited the same late component, albeit with a larger amplitude. This enhancement was temporary: decreasing amplitude was observed in the course of CS test presentations under extinction. Prior research revealed a comparable slow component in the amygdala of the cat under similar experimental conditions. The collective results indicate that the large late component in the amygdala is enhanced by fear conditioning, suggesting that such enhancement reflects the anticipation of a biologically significant event